Feed Strategy - October 2019 - 25

FeedStrategy ❙ 25

Concerns have been raised in
recent decades that subtherapeutic
use of antibiotics hastens the spread
of antibiotic-resistant bacteria.
Mixed opinions still exist whether
the use of antibiotics as growth
promoters (AGPs) really plays a role
in the transfer of resistance from
animal pathogens to human pathogens. What is clear, however, is that
these concerns have led more and
more consumers, as well as regulatory authorities, to push to curtail
AGP use, steering the industry
toward antibiotic-free feeding.

Finding AGP alternatives
The search for alternatives to
AGPs has become a priority in
the animal food-producing sector.
There are many additives available on the market that serve as
alternatives. Yet, although the use
of AGPs has been proven to show
reproducible results in animals, the
mode of action of AGPs remains
unclear and debates are ongoing in
the scientific community.
The dosages applied when
antibiotics are used as AGPs are
lower than the minimum inhibitory concentration (MIC), which
is the level needed to make sure
the bacterial growth is inhibited
(known as bacteriostatic effect).
This indicates that the dosage is
too low to be able to suppress the
growth of pathogens in the gut
and has also been confirmed by
numerous scientific studies.
Nevertheless, the use of AGPs
has been proven to have effects
related to the shift of the microbial
October 2019 ❙ www.FeedStrategy.com

Proposed modes of action of AGPs
Mechanism

Reference

Anti-inflammatory effect

Niewold, 2007

Promotion of a balanced gut microbiota

Gaskins et al., 2002; Costa et al., 2017

Improved fat digestiblity and energy uptake Lin, 2014
Quorum quenching

Broom, 2017

Reduction of bacterial growth

Reeks et al., 2005

Source: BIOMIN

Various proposed AGP modes of action have been identified, including antiinflammatory, microbiota balance, improved digestibility, quorum quenching or
inhibition and slowed bacterial growth rates.
community in the gut and very
often bacteria involved in these
shifts are lactobacilli, which are
also considered to have positive and
negative effects on performance.
Clearly, the gut microbiota
plays a very important role by
ensuring a good performance, but
still more research is needed in
order to better understand how
an optimal animal gut microbiota
should look. For this reason, it
remains difficult to choose alternatives to AGPs in relation to their
effect on the microbial population
in the gastrointestinal tract.

Exploring feed additive
alternatives
There are other proposed modes
of action of AGPs seeming to
be important for a good animal
performance. These proposed
mechanisms could be addressed
with alternative products available

on the market.
Examples for the modes of
action that could be targeted are:
■ the anti-inflammatory exerted
by antibiotics,
■ the promoted balance of the
microbiota,
■ a better digestibility of fat and
energy uptake,
■ the quorum-quenching or inhibition of cell-to-cell communication effect of antibiotics at
sub-lethal dosage,
■ the capacity of antibiotics to
slow down the growth rate of
some bacteria also at dosages
below MICs.
Food animals are subject to
many factors that can lead to inflammation, which results in "wasted"
energy that could otherwise be put
toward performance. Plant-based
substances with anti-inflammatory
effects can limit energy wastage,
thereby promoting growth.

GROWTH HACKING UNCOVERS HOW
antibiotic growth promoters work
and finds novel additives to boost
performance.


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Feed Strategy - October 2019

Table of Contents for the Digital Edition of Feed Strategy - October 2019

Feed Strategy - October 2019
Contents
In the Mix
Industry Happenings
Consumers, weather, trade sway 2019 dairy feed volumes
Tips for maximizing forage in ruminant rations
How to replace corn with wheat in modern animal diets
Marketing nutrition by following trends
What AGPs can teach us about growth promotion
Broad review of research presented during 2019 ESPN
Grinding: benefits of particle size modifications
Products
Advertisers’ Index
Feed Strategy - October 2019 - CT1
Feed Strategy - October 2019 - CT2
Feed Strategy - October 2019 - Feed Strategy - October 2019
Feed Strategy - October 2019 - Cover2
Feed Strategy - October 2019 - CT3
Feed Strategy - October 2019 - CT4
Feed Strategy - October 2019 - Contents
Feed Strategy - October 2019 - In the Mix
Feed Strategy - October 2019 - Industry Happenings
Feed Strategy - October 2019 - Consumers, weather, trade sway 2019 dairy feed volumes
Feed Strategy - October 2019 - 5
Feed Strategy - October 2019 - 6
Feed Strategy - October 2019 - 7
Feed Strategy - October 2019 - 8
Feed Strategy - October 2019 - 9
Feed Strategy - October 2019 - Tips for maximizing forage in ruminant rations
Feed Strategy - October 2019 - 11
Feed Strategy - October 2019 - 12
Feed Strategy - October 2019 - 13
Feed Strategy - October 2019 - 14
Feed Strategy - October 2019 - 15
Feed Strategy - October 2019 - How to replace corn with wheat in modern animal diets
Feed Strategy - October 2019 - 17
Feed Strategy - October 2019 - 18
Feed Strategy - October 2019 - 19
Feed Strategy - October 2019 - 20
Feed Strategy - October 2019 - 21
Feed Strategy - October 2019 - Marketing nutrition by following trends
Feed Strategy - October 2019 - 23
Feed Strategy - October 2019 - What AGPs can teach us about growth promotion
Feed Strategy - October 2019 - 25
Feed Strategy - October 2019 - 26
Feed Strategy - October 2019 - 27
Feed Strategy - October 2019 - Broad review of research presented during 2019 ESPN
Feed Strategy - October 2019 - 29
Feed Strategy - October 2019 - 30
Feed Strategy - October 2019 - 31
Feed Strategy - October 2019 - Grinding: benefits of particle size modifications
Feed Strategy - October 2019 - 33
Feed Strategy - October 2019 - 34
Feed Strategy - October 2019 - 35
Feed Strategy - October 2019 - 36
Feed Strategy - October 2019 - 37
Feed Strategy - October 2019 - Products
Feed Strategy - October 2019 - 39
Feed Strategy - October 2019 - Advertisers’ Index
Feed Strategy - October 2019 - Cover3
Feed Strategy - October 2019 - Cover4
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